Sociology and the post-pandemic world: reconstructing a sustainable society

The social crisis

We are living in an unusual time. The world has suddenly come to a standstill, with closing down of businesses, and human life restricted. The pandemic crisis of COVID-19 has forced the global citizens to remain in their homes amid lockdown and content themselves with the simpler pleasures of life.

Along with the rising fear and uncertainty, the lockdown has also induced domestic violence, child abuse and depression. Society is going through an unprecedented condition, tackling new challenges from various spheres. A grave social crisis has manifested itself, there is unhappiness, and depression in the homes on the one hand, and economic crisis on the other. Such conditions are unsuitable for any society to survive and prosper.

 After we survive

The post COVID-19 world would be required to be remade, keeping in mind what will be at stake in the event of us failing to do so. A society rife with inequality, deprivation, and gender discrimination is an unsustainable society, as has been clearly proven in the past few months; that we are far away from gender equality, in spite of what the feminist movements have achieved for decades, and that a large section of the population of India is living at the margins, who are bearing the heavy brunt of closing down of business due to lockdown. Sociologists, worldwide, are concerned about the various challenges and new social problems that have manifested, as people have been restricted in their homes, forced to cohabit for months without a break, and a large section of the population losing their only means of subsistence.

Understanding Sociology in view of the pandemic

Sociology plays a central role in understanding the extent of the pandemic, the gravity of the social crisis it has generated, as well as an insight into the most vulnerable sections of the population affected. The unbridled urbanization in the 21st century India and the unplanned growth and extension of the cities has also brought with it the gift of slums in numerous areas. With the rising land prices in cities in India, people are forced to settle in ‘jhopris’, for whom, the city ensures the means of subsistence. Extremely close habitation in such places, in addition to common toilets and overall problems of sanitation, has often been mentioned in newspaper headlines, in the event of a disease outbreak like cholera or malaria in the past. But hardly, much is done about it either by the government, political parties or non-governmental organizations. Thousands of labourers migrate to the city in search of jobs, and the only way they could afford to live in the city is in slums.

But, in order to safeguard against covid 19, physical distancing is of utmost importance, a principle which is literally impossible to follow in informal slum settlements. And this time, the government cannot ignore the dire consequences that can result from living in such close proximity. The present corona virus outbreak in Dharavi, in Mumbai, is a case in point. Such problems of a developing country like India could be only addressed by methodological tools of Sociologists, who are trained in field research and scientific observation, and who possess a sound understanding of the culture of the social group they are studying, without prejudice. This makes them unparallel in understanding the social problems in their depth and offering possible solutions.

The crucial role of Sociologists

The government would invariably depend on the Sociologists to understand numerous social problems, for example, the problems encountered by migrant labourers, who have been stranded as a result of the lockdown due to the pandemic. The administration cannot brand them as ‘agitators’, since these are the ground-level workers upon whose shoulders the nation stands. In the event of loosing their jobs, and unable to reach home hundreds of miles away, the responsibility of their care rests with the government. But without due research, and in-depth understanding of the specific problems, solutions have proven to fail. The only people capable of that kind of research with scientific methodology are the Sociologists. With the economy being hit hard, job losses and price rise are bound to follow in the post pandemic world. But with the right research and appropriate policy initiatives, we can prevent the society from descending into poverty and deprivation. By understanding the causes of deprivation and the specific needs to empower the population by generation of resources, we can help in creating a better world.

Sociology, as a discipline, provides the critical insight into society that would be required in the new world. After the world survives the catastrophic wreck left behind by the virus pandemic, India as a nation would require effective social policies to tide over the crisis and rejuvenate. The reformulation of policies of rural and urban development, with an emphasis on sustainability would require the expertise of Sociologists. Methodical observation, and scientific analysis of the social problems could only lead to a better understanding of the problems itself and eventually its solutions. Thus, I believe, in the new world, the services of the Sociologists would be of utmost importance to the national and international community to build a better tomorrow.

New-age nanotechnology-based therapeutics against the virus SARS-COV-2

Student contributor: Moni Kumari, B.Sc. Biochemistry 

Coronavirus disease (COVID19) is an infectious disease caused by a newly discovered coronavirus, SARS-COV-2 (Severe acute respiratory syndrome-coronavirus-2) identified in Wuhan, and responsible for Pneumonia outbreak throughout the world. This outbreak was started in China in December 2019 and become worldwide within a timeframe of a few months. World Health Organization recognized it as a pandemic on 11th March 2020. So far, more than 2 million people around the world have been infected with this virus with an increase in the number of deaths that is being reported every day. Importantly, developed nations are more affected by a higher number of casualties.

Nanotechnology is an important area of research dealing with designing noble nanoscale particles with an application in a wide area of science. Unlike other new-generation drugs having large molecular structures, nanoparticles are so small that they can move through our body and blood circulatory systems without disrupting other functions, such as our immune system. Scientists around the world are working constantly to device new nanoparticles to address the current situation of COVID-19.

This scanning electron microscope (SEM) image shows SARS-CoV-2 (round gold objects) emerging from the surface of cells cultured in the lab. The nanoscale dimension of coronavirus was revealed in this image.  (Image: NIAID-RML)

  1. Nanoparticle diagnostic kit: Conventional diagnostic kits commercially available today for the detection of coronavirus are not very accurate and also in short of supply. Additionally. It needs the extraction of total RNA sample from the patient for detection. To overcome these problems research groups from the Norwegian University of Science and Technology (NTNU) design new iron oxide-based nanoparticles coated with silica. The iron oxide confers its magnetic properties to nanoparticles and silica coating gives it a strong affinity for RNA, the genetic material inside the virus that causes COVID-19. The new test uses the magnetic properties of nanoparticles to extract RNA from a solution containing a test sample from the patient. The solution contains substances that crack the virus open so that its genetic material can be extracted. RNA from the virus in the solution is strongly attracted to the silica-covered magnetic nanoparticles. The next step is to use a magnet to pull the RNA-covered particles out of the solution and submit it for RT-PCR. Importantly, this kit has been used successfully to test more than 1,50,000 COVID-19 patients in Norway.

 

  1. Nanoparticle vaccine: Vaccine is a dead or weakened antigen that provokes our immune system to create antibodies before the body is exposed to the live viruses. Scripps research from San-Diego USA is trying to develop a nanoparticle-based platform for vaccines against coronavirus. The prototype of the vaccine possesses CoV-2 spike protein protruding from a protein nanoparticle scaffold. Thus, the nanoscale platform is going to mimic like a virus (virus-like particle) which upon vaccination can induce our immune system to rapidly generate antibodies against coronavirus, offering recipient protection against the real SARS-CoV-2 virus. The Research group has recently applied for a patent with the name of one component self-assembling protein nanoparticle (1cSApNP)vaccine.

 

  1. Nanobots or Nanorobots with Theranostic properties: Researchers from Northwestern University, Illinois are trying to device more advanced nanoparticles which can possess both properties of detection and neutralization of virus particles. Theranostic is an advanced area of research of designing molecules with both diagnosis and therapeutic power. The surface of this newly designed smart nanoparticles is going to carry biological molecules (Furin peptide) that can bind coronavirus with a very high affinity and thereby detect and assemble them. The same nanoparticle can encapsulate with biological substances that can neutralize the viruses. The biological substance can be bee venom which was proven earlier in the neutralization of HIV. Biological nanoparticles are preferable in comparison to chemically synthesized particles as they have fewer side effects. Thus these smart nanoparticles can work like a nanorobots and roam around in our blood vessels while detecting and killing the pathogenic virus.

Corona and Isolation: How lonely we are

গত এক মাস ধরে বেশ কিছু নতুন শব্দ আমাদের দৈনন্দিন জীবনের সঙ্গে জড়িয়ে গেছে। তার ভিতরে সবথেকে বেশি শুনছি ‘কোয়ারেন্টাইন’, ‘আইসোলেশন’ ও ‘সোশ্যাল ডিসট্যান্সিং’। এই সমস্ত শব্দের ভিড়ে মানুষকে যেটা খুব দ্রুত রপ্ত করে নিতে হয়েছে তা হলো পারিপার্শ্বিক মানুষ ও পরিস্থিতি থেকে বিচ্ছিন্ন হয়ে অনেকটাই ‘একা’ বাঁচতে শেখা, শুধুই নিজের পারিবারিক গণ্ডীর ভিতরে। এর ভিতরেও নিত্যদিনের যার যা যা কাজ চলছে ডিজিটাল মাধ্যমে; ভার্চুয়াল যোগাযোগে আমরা সবাই নির্দিষ্ট সীমানার ভিতরে বন্দি। মানবিক স্পর্শের প্রত্যক্ষ উত্তাপ থেকে আমরা বেশ অনেকটাই দূরে। এক মাসের বেশি সময় ধরে আমরা অফিস, স্কুল, কলেজ, আড্ডা, সিনেমা হল, চায়ের দোকান— সবকিছু থেকে দূরে। তাই অনেক কাজের ভিতরেও আমাদের মনে একঘেয়েমি আসছে, ‘একলা’ হয়ে যাওয়ার অনুভূতিও হচ্ছে। 

এখন প্রশ্ন হল— মানুষ কোন সময়ে একলা নয়? জন্মের সময়ও তো আমরা একলাই ছিলাম। মৃত্যুর সময়ও তো সে-ই একলাই চলে যেতে হবে। তাহলে আমরা কোথায় কখন একলা নই? ঐ জন্ম আর মৃত্যুর মাঝামাঝি যে পথটুকু যাকে আমরা ‘জীবন’ বলে চিনি সেখানে আমরা দৃশ্যত একলা নই। সেখানে আমাদের ঘিরে থাকে পরিবার-আত্মীয়-অনাত্মীয়-বন্ধু-পরিজন। কোরোনার এই দুঃসময়ে আমরা আমাদের আত্মীয়-পরিজন-বন্ধু-সহকর্মীদের থেকে শারীরিক দূরত্ব বজায় রেখে জীবন-যাপন করছি। একটু একটু করে ক্লান্ত হয়ে যাচ্ছি। কিন্তু একইসঙ্গে কেমন যেন অভ্যস্তও হয়ে যাচ্ছি, তাই না? এই গৃহবন্দি দশার একদম শুরুতে আমরা যতটা অস্থিরতা আর অনিশ্চয়তায় কাতর ছিলাম এক মাসে কেমন যেন একটা ‘নিজেকে নিজের মতো গুছিয়ে নিয়েছি’ আমরা।

প্রকৃত অর্থে, আমরা কোরোনার এই দিনগুলোর আগেও একাই বাঁচতাম। শারীরিক দূরত্বটুকুই নতুন সংযোজন মাত্র। মনে মনে তো আমরা পাশাপাশি বসে গল্প করতে করতেও একাই বাঁচতাম। কেউ কেউ প্রশ্ন তুলবেন, ‘কেন আত্মীয়-বন্ধু-পরিজন এরা কি ছিল না নাকি নেই?’। উত্তরে বলব, ‘ছিল, আছে। কিন্তু এই থাকাকে কি থাকার মতো থাকা বলা যায়?’। প্রতি মুহূর্তে অসূয়া, পরশ্রীকাতরতা, বিনিময় প্রথার চুলচেরা বিশ্লেষণ, বাড়ি-গাড়ি-বেতনের তুল্যমূল্য নির্ধারণ— শুধুই অঙ্ক কষে কষে আসলে আমরা আসল অঙ্কটাই গুবলেট করে ফেলছি!

আসল অঙ্ক— ঐ যে জন্ম থেকে প্রত্যেকদিন আমরা একটা বিয়োগের ভিতর দিয়ে এগিয়ে চলেছি মৃত্যুর দিকে। যতই বস্তুগত যোগফল দেখে খুশি হওয়ার চেষ্টা করিনা কেন বিয়োগের অঙ্ককে থামিয়ে ফেলি এমন সাধ্য আমাদের নেই! কোরোনার মহামারী এরকম লক্ষ লক্ষ বিয়োগের দৃষ্টান্ত আমাদের চোখে আঙুল দিয়ে দেখিয়ে দিচ্ছে। প্রতিদিন বিশ্বের নানা প্রান্তে মানুষ কাছের মানুষকে হারিয়ে ফেলছে, নিরুপায় কান্নায় ভেঙে পড়ছে অথচ শেষ দেখাটুকুও দেখতে পারছেনা। ের থেকে বেশি করুণ অভিজ্ঞতা আর কি হতে পারে মানুষের জীবনে? ‘একলা’ ঘরবন্দি মানুষ— মানে আমরা এই বিয়োগের অঙ্ককে তাই প্রতি মুহূর্তে ভয় পাচ্ছি। আর সেই ভয়কে এড়িয়ে থাকতে চাইছি রান্না, গান, কবিতা, ছবি, সাহিত্য, সিনেমার আড়ালে। আমাদের  মধ্যে যারা এই কোরোনার সমানুপাতিক বিয়োগের অঙ্ককে আপাতত এড়িয়ে যেতে সক্ষম হব, এই একলা দশা কাটিয়ে আবার ‘সবার সঙ্গে একসঙ্গে’ হওয়ার সুযোগ পাব তারা নিঃসন্দেহে ভাগ্যবান।

কিন্তু প্রশ্নটা হল— তারপর? জীবন যখন আমাদের দ্বিতীয়বার সুযোগ দেবে তখনও কি আমরা মনে মনে একলা হয়েই বাঁচব? মানুষকে ভালবাসব না? ক্ষমা করতে শিখব না? ঈর্ষার পরিবর্তে একাত্মতা, পরশ্রীকাতরতার পরিবর্তে সহজ আনন্দ, হিসেবের পরিবর্তে একটু বেহিসেবি প্রাণের টানে আত্মীয়-বন্ধু-পরিজনকে কাছে টেনে নেব না? মনোমালিন্য, আত্মগরিমা, বিদ্বেষ, অভিযোগ— এক জীবনে যদি এসবেই সময় চলে যায় শেষের সেদিন কী নিয়ে বিদায় নেব? শুধুই ‘একলা’ থাকার চিরগ্লানি ছাড়া আর কিছুই পাথেয় হবে না শেষযাত্রায়!

কঠিন সময় আসলে আমাদেরকে সবকিছুরই প্রকৃত মূল্যায়ন করতে শিখিয়ে দেয়। কারণ তখন কোনকিছুই সুলভ হয়না। আমাদের কাছে এখন সবথেকে গুরুত্বপূর্ণ পেট চালানোর মতো খাবার এবং দরকাই ওষুধ সংগ্রহ করে রাখা। দিন দিন নতুন নতুন রোগ আবিষ্কার হচ্ছে, নতুন নতুন ওষুধ আবিষ্কার হচ্ছে। আর সেইসব বহুমূল্য ওষুধের অপরিহার্যতা বিষয়ে আমরা ক্রমশ স্বশিক্ষিত হয়ে উঠছি। কোরোনার প্রতিষেধক আবিষ্কার নিয়ে সারা বিশ্বের চিকিৎসাবিজ্ঞান রাতদিন মগজ খাটিয়ে চলেছে। সেই চেষ্টা নিয়েও প্রতিযোগিতা শুরু হয়েছে— কোন দেশ সবার আগে আবিষ্কার করতে পারে সেই প্রতিযোগিতা। কোনও দেশই এই কঠিনতম সময়ে ভাবতেই পারছেনা নানা দেশের সেরা সেরা মাথাগুলো নিজেদের গ্রে ম্যাটার বিনিময় করে যদি সবাই একসঙ্গে চেষ্টা করে তাহলে হয়তো প্রতিষেধক আবিষ্কারের ব্যাপারটা খানিক ত্বরান্বিত হলেও হতে পারে! জীবনদায়ী ওষুধের মতোই এই মহামারীর সঙ্গে লড়াই করার জন্য আমরা অপেক্ষায় আছি সেই প্রতিষেধকের।

মানুষ যখন জন্মায় তখন সে দুটো প্রতিষেধক নিয়েই জন্মায়— মা ও বাবা। এরপর আমৃত্যু বিয়োগের অঙ্কের দিকে এগোতে এগোতে তাকে নানাবিধ রোগব্যাধির হাত থেকে বাঁচতে নানাবিধ ওষুধ খেতে হয়। কিন্তু খুব কম মানুষই আছেন যারা একটা অমোঘ জীবনদায়ী ওষুধের খোঁজ পান। এই অমোঘ জীবনদায়ী ওষুধের নাম ‘সম্পর্ক’— যা আমাদের চিরবিয়োগের পরেও থেকে যায়। এই কোরোনার একা ঘরবন্দি হয়ে থাকার দিনগুলোয় শীতল হয়ে আসা সম্পর্কগুলোকে আরেকবার উষ্ণ করে তোলার চেষ্টা করাই যায়, তাই না? সমস্ত জাগতিক সাফল্য ও ব্যর্থতার শেষে মানুষের সঙ্গে মানুষের সম্পর্কই সেই একমাত্র ওষুধ যা আমাদের জীবনের ভয়াবহ ক্ষত, ব্যাধি, যন্ত্রণা সবকিছুকে সারিয়ে দিয়ে বিয়োগের অঙ্ককেও তুচ্ছ করে দিতে পারে। জীবনের সঙ্গে জীবনের যোগেই একমাত্র এই জীবনদায়ী শক্তির খোঁজ পাওয়া সম্ভব; অন্য কোনও বিনিময় নেই।

পৃথিবীর মৃত্যুমিছিলে বারবার মনে হচ্ছে আসলে বেঁচে থাকাটাই একটা আশ্চর্য ব্যাপার, মরে যাওয়াটাই সহজ ও স্বাভাবিক! কিন্তু মানুষই পেরেছে আশ্চর্যকে সহজবোধ্য করে তুলতে। মানুষই হয়তো পারবে একদিন ‘একলা’ থেকে ‘সবাই’ হয়ে উঠতে। শুধুই শারীরিক দূরত্বের নিরিখে নয়, মনের সঙ্গে মনের যোগাযোগে— তবেই জীবনের জয় সম্ভব। কোরোনা তো কদিন পরে নিজের নিয়মেই চলে যাবে এর আগে কয়েকটি শতাব্দীতে যেভাবে কলেরা, প্লেগও চলে গিয়েছিল। কিন্তু মানুষের জীবনকে, আমাদের এই অতি প্রিয় পৃথিবীকে কষ্টকল্পিত নরকের চেয়েও দুঃসহ করে দেওয়ার জন্য আরও অসংখ্য অদৃশ্য জীবাণু মানুষ নিজের মনের ভিতরেই পুষে রেখেছে। ওরা কোরোনার থেকেও ভয়ঙ্কর, ওরা আমাদের ভিতরে ভিতরে মেরে ফেলার পরেও আমরা বুঝতে পারিনা যে আমাদের ভিতরের মনুষ্যত্বটা মরে গেছে। তাই ওরা আমাদের সবটুকু মেরে ফেলার আগে আমাদেরই ওদের মেরে ফেলতে হবে। আমরা এখনও আধমরা হয়ে আছি। সবটুকু মরে যাইনি। সবটুকু শক্তি নিয়ে যুদ্ধ করলে এখনও ওদের সমূলে শেষ করে দিতে পারি। এই একলা থাকার মরশুমে আমরা সবাই নিজের নিজের একান্ত নিজস্ব পরিসরে আছি। এইটাই তো আদর্শ সময় যখন আমরা নিজেরা নিজেদের মুখোমুখি দাঁড়াতে পারি দ্বিধাহীন ভাবে; বন্ধ দরজার ভিতরে নিজের ঘরের আয়নার সামনে দাঁড়িয়ে এখনই নিজেকে প্রতিশ্রুতি দিতে পারি যে মনের ভিতরের ওইসব আত্মঘাতী জীবাণুদের চিরতরে বিনাশ ঘটিয়ে একটা ‘নতুন আমি’ হয়ে উঠবো।

তারপর, একদিন সকালে আমরা সবাই বুকের মাঝে রবি ঠাকুরের গান নিয়ে ঘর থেকে বাইরে পা রাখবো সম্পূর্ণ নির্মল পৃথিবীতে, ‘আপন হতে বাহির হয়ে বাইরে দাঁড়া, বুকের মাঝে বিশ্বলোকের পাবি সাড়া’…

COVID-19: Present remedies and link to Air Pollution

Student Contributor: Soham Biswas

In December 2019, while the Christmas Eve was approaching near, several patients in the Wuhan district of China were diagnosed with ruthless pneumonia caused by an unknown virus. In response, an epidemiological alert was placed by the World Health Organization (WHO) on December 31, 2019.

By January 7, 2020, Chinese scientists had isolated the causative agent and named the virus as the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). In a few months that followed, the virus spread its cruelty across far-off countries resulting in the present-day infamous pandemic situation of the coronavirus disease 2019 (COVID-19). No doubt, it is one of the most desperate situations that the world has seen in recent times as many of the countries face a complete lockdown. About 80% of the patients remain asymptomatic being only the carrier of the disease and mostly remain undetected. So, the virus could infect more and more people while causing deaths of the more vulnerable ones. It has been observed that most susceptible ones are the old age people, the ones with the compromised immune system and pre-existing respiratory ailments, the new-borns and the expected mothers. It has also been found that the immune system of patients with SARS-CoV-2 infection gets drastically affected as the surviving T-cells are functionally exhausted, suggesting that, they are at potential risk of developing secondary infections that cannot occur if the immune system is strong and healthy. With a mortality rate of less than 7% the virus has already claimed 1.4 lakh lives worldwide and infected more than 20 lakhs within just five months of its outbreak recorded to date. But unfortunately, this is not the actual number, since the number of tests done to detect the disease is much less in most of the countries. Therefore, the actual number of the unlucky people infected with this RNA virus could be much larger and this points a serious concern.

No one in their wildest imagination could have ever thought that someday a mutant flu virus would cage them in their homes and make them go to banks and markets while dressing like a robber, such as the dramatic impact of the COVID-19. According to a recent study, it has been observed that air pollution could be an important issue in the enhanced severity of the infection. It has been proposed that prolonged exposure to air pollution could impair the first line of defense of upper airways, such individuals are at a higher risk of developing acute respiratory disease syndromes(ARDS). They are much more vulnerable to being invaded by the virus as it could easily surpass the already weakened upper respiratory defenses while reaching the lower airways. In that case, it would cause a heavy toll on the already weakened immune system and the effect could be fatal. Since the modification of the immune system had taken place through prolonged exposure to pollution therefore short term improvement in air quality would not improve the immune power of individuals. This might be the case of Lombardy and Emilia Romagna of northern Italy, which were the two most polluted areas of Europe. Despite, the drastic reduction in pollution the mortality rates due to infection has not quite lowered there. Perhaps the first lesson to counter the pandemic should be to lower the pollution and live in complete harmony with nature. Though nothing is proved yet, air pollution could be a cause that will increase the death rate of this particular infection.

        To combat this dire situation, our valiant battalions of scientists and doctors, have launched large scale research at the frontlines to quickly find out a remedy to the disease. Right now there is no available drug or vaccine that is present to fight against this deadly virus. So, repurposing of existing various drugs could be a successful alternative to counter the disease since the time is very short and the development of a particular vaccine would take a longer time.

Many compounds have been found to have a probable clinical advantage against the virus. Notable among them, are:

  • Chloroquine and Hydroxychloroquineare the compounds that prevent the generation of inflammatory signals. Biochemically, it interferes with the interaction of the toll-like receptor(TLR)  and the mature virion and prevents the cytokine production.

 

  • Oseltamivir is a neuraminidase inhibitor that is thought to disrupt the virus-host cell interaction. In India, it is already prescribed to patients suspected to have COVID-19 and are already displaying mild symptoms like low-grade fever, cough, malaise, rhinorrhea, sore throat without shortness of breath.

 

  • Arbidol (Umifenovir) has shown a promising inhibitory effect in lowering the reproduction rate of the virus in vitro. Currently, this drug is under phase 4 clinical trial.

 

  • Ribavirin prevents the replication of RNA virus by acting as a nucleoside analog and suppressing the activity of inosine monophosphate dehydrogenase which in turn downregulates the synthesis of guanosine triphosphate (GTP). Ribavirin had been widely used to treat SARS patients in Hong Kong. Thus, it could be a possible option for COVID-19 treatment.

 

  • Ritonavir and Lopinavir have been found to bind to the proteinase 3CL-pro of the SARS-CoV-2 that cleaves the polyprotein at 11sites from the C-terminus and inhibits its function, thereby disrupting protein expression. Thus is a promising drug that could be used often in combination with other drugs.

 

  • Darunavir and Cobicistat are HIV protease inhibitors. Currently under the phase 3 clinical trial.

 

  • ASC09F is also an HIV inhibitor currently under phase 3 clinical trial in combination with Oseltamivir.

Remdesivirand Favipiravirare Inhibitors of RNA polymerase hence thought to be used against the SARS-CoV-2 which is an RNA virus.

Apart from these compounds, with the help of bioinformatics analysis, a compound namedBaricitinib has been identified to be helpful as it could inhibit the enzyme AP-2-associated protein kinase 1 (AAK1) that plays an important role in the cellular entry of the virus. Another compound camostat mesylate, that inhibits the enzyme TMPRSS2 that is involved in the maturation of the spike protein on the virion could also be helpful. By using the principles of RDT a soluble recombinant ACE2 protein has been designed that could competitively bind to the virus and prevent its binding to the membrane-anchored version of the receptor. This innovation has worked well in vitro and monkey models and could perhaps effectively combat the disease.  Antiviral therapy using the Interferon-alpha (IFNα) also looks promising as it could directly interfere with the viral replication and prevent its spread. Tocilizumab, an inhibitor of interleukin 6 is also reported to be useful in severe cases of COVID-19 with elevated IL-6.

Certain Chinese traditional medicine has also surfaced as a potential means to treat the pandemic and is consequently being investigated. Notable, among them, are:

  • Glycyrrhizin, an active component of licorice roots that could competitively bind to ACE2 and also efficiently disrupted the replication of SARS-CoV-2 in-vitro.
  • Baicalin, isolated from Scutellaria baicalensis the famous Chinese skullcap, is a flavone that has exhibited certain antiviral activity.
  • Quercetin, another compound has been reported to exert antiviral activity by blocking host cell entry and disrupting the action of  the viral protienase 3CLpro.
  • Hesperetin, a compound isolated from citrus fruits inhibits the cleavage activity of the 3C-like protease (3CLpro).

Apart, from these Chinese ‘nuskhas’, different immunotherapeutic approaches are also being taken. One of these is Convalescent plasma therapy, where the convalescent plasma of the recovered patient is used to treat the newly infected has been started.

Though we do not have any scientifically recommended remedy to this particular disease right now, there are many current possibilities to counter the virus and we can hope that the battle won’t last long for it is just a matter of time, when we would have our perfect remedy and then just like in every era we would emerge victorious in the race of the survival of the fittest.

Transmedia Narrative and New Age Learning – Teaching Literature effectively

transmedia narrativeThe worldwide lock down has shifted the teaching learning experience entirely on to the digital platform. As teachers we often ponder on the question as to how to engage our students more effectively when the only medium available is the internet. In the absence of a direct interaction, getting the student’s attention becomes quite challenging. In such a scenario an alternative method of evoking interest in the students is experiential learning. This not only makes studying interesting, but it also provides a more holistic approach to a student’s understanding. In this context I would like to talk about using Transmedia Narrative in the teaching learning process. Though this can be used across various disciplines, as a faculty of English Literature, I will be focusing mainly on the domain of literature.

What is Transmedia Narrative?

The traditional method of studying a text has been textual analysis through lectures. In the present age only depending on explanation of a text through lectures becomes quite insufficient. This is where Transmedia Narrative plays a very important role. Before moving forward, I would like to discuss what this particular form of narrative refers to. The manner in which literary texts are consumed are no longer restricted to passively reading a text whether in the form of a hard copy or its electronic copy. Transmedia narrative refers to the various mediums which can be used to depict a particular literary text like a movie, a game, interactive fiction, comic strip, art , installation to name a few. When a literary work is presented through the different mediums, its representation and consumption, greatly differs from one to the other. Passive consumption has been replaced by immersive learning which transforms the passive audience to an active one in most cases.

Tools of learning through transmedia storytelling:

There are various mediums available in the market today which could be exploited to cater to the differing student understanding. Read ahead to know more about the various platforms at the disposal of teaching professionals to creatively engage their students in the process of learning.

  • Movie adaptations has been the earliest form of transmedia representation of a text. Movies help the readers to put the text in context and acquire greater understanding through its visual representation. This was followed by games based on texts. In this medium the audience becomes an active participant in the unfolding of the narratives. One such example is the Lord of the Rings multiplayer online game. This game is closely structured on J.R.R Tolkien’s The Hobbit and the Lord of the Rings series. There are multiple quests in the game and how it is played depends entirely on the players. There is a choice of characters built on the characters appearing in the novels. The story world gives a better understanding of the text as the students can access the characters and setting directly.
  • Interactive fiction is another medium which provides the students with the option of active participants. One of the foremost software used for interactive fiction is Inkle. Interactive fiction allows the reader to read a text in the sequence which he/she chooses to follow. As a reader the student can choose one ending out of multiple endings each with a different plot line.
  • Minecraft is another tool which can be used to create story worlds based on the settings of text which can then be traversed by the students. This helps in retaining important details pertaining to a particular text. ArcGIS storymaps can be used to chart the places included in a text. Teachers can use existing story maps or make one.

Digital platform has become indispensable to teaching learning pedagogy in the present time. These tools and the sphere of transmedia narrative can be used for the dissemination of knowledge of any discipline. Though this form becomes essential during the long periods of lockdown, its use can be continued beyond the time of isolation as the education industry has started moving towards the digital domain as a major effect of the Covid-19 outbreak.

External Links:

What Awaits India Post-COVID-19 Lockdown: Analysis

Education

One sector that would see a transformation in the post-COVID period is education. Though the current academic year has gone topsy turvy, experts say the Indian education system has the dynamics to absorb disturbances from one semester to two.

While the federal and state governments have decided to promote all students in the primary classes – 1-8th standard, those in the higher classes and colleges are stuck, as they could not complete their annual examinations.

 “It is a global phenomenon and barring the delay, I don’t think it would affect the ongoing academic year of students,” said an official of the federal Human Resource Development Ministry, who did not wish to be named.

“During the last two years, online education has picked up. Now with the present situation, it may get strengthened.  16 million students have already enrolled for various courses through the online system, and get the credit transferred to their conventional evaluation up to 20 percent,” he added.

“The educational system can absorb three to six months of break,” said Professor Ujjwal K. Chowdhury, Pro Vice Chancellor of Adamas University in Kolkata. Professor Chowdhury said, this would also trigger a new revolution in education in India – from traditional to e-learning system. He however, said access to stable and high-speed internet and laptops are fundamental for such a system. 

“Many universities and educational institutions have already adopted such a method of teaching, digital mentorship, where the teacher has to engage his students. It is a challenge to teachers and students. Unlike a conventional educational system, digital learning is interactive and collaborative,” said Professor Chowdhury. 

This blog was first published by The SputnikNews. Click here to read original article.

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